2025
- Multiple oestradiol functions inhibit ferroptosis and acute kidney injury.Nature. 2025 Sep;645(8082):1011-1019. doi: 10.1038/s41586-025-09389-x. Epub 2025 Aug 13.PMID: 40804518
- Aberrant Mitochondrial Metabolism in Alzheimer’s Disease Links Energy Stress with Ferroptosis.Alves F, Lane D, Wahida A, Jakaria M, Kalinowski P, Southon A, Belaidi AA, Samperi-Esteve T, Nguyen TPM, Lei P, Krueger M, Mueller S, Conrad M, Agarwal P, Leurgans SE, Schneider J, Bush AI, Ayton S.
Adv Sci (Weinh). 2025 Jul 8:e04175. doi: 10.1002/advs.202504175. Online ahead of print.PMID: 40625200
- Recommendations for robust and reproducible research on ferroptosis.Nat Rev Mol Cell Biol. 2025 Aug;26(8):615-630. doi: 10.1038/s41580-025-00843-2. Epub 2025 Apr 9. PMID: 40204928
- Loss of apolipoprotein E contributes to inflammatory macrophage activation and ferroptosis in NSAID-exacerbated respiratory disease.
Schmiz G, Haimerl P, Ram I, Kulagin M, Spitzlberger B, Henkel FDR, Hartung F, Schindela S, Rao Z, Koeberle A, Schmidt-Weber CB, Chaker AM, Lechner A, Esser-von Bieren J.
J Allergy Clin Immunol. 2025 Jun 19:S0091-6749(25)00652-9. doi: 10.1016/j.jaci.2025.06.010. Online ahead of print.PMID: 40543901
- The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis.
Woo MS, Brand J, Bal LC, Moritz M, Walkenhorst M, Vieira V, Ipenberg I, Rothammer N, Wang M, Dogan B, Loreth D, Mayer C, Nagel D, Wagner I, Pfeffer LK, Landgraf P, van Ham M, Mattern KM, Winschel I, Frantz N, Sonner JK, Grosshans HK, Miguela A, Bauer S, Meurs N, Müller A, Binkle-Ladisch L, Salinas G, Jänsch L, Dieterich DC, Riedner M, Krüger E, Heppner FL, Glatzel M, Puelles VG, Engler JB, Nyengaard JR, Misgeld T, Kerschensteiner M, Merkler D, Meyer-Schwesinger C, Friese MA.
Cell. 2025 Jun 13:S0092-8674(25)00616-6. doi: 10.1016/j.cell.2025.05.029. Online ahead of print.PMID: 40532699
- Sex-specific lipidomic signatures in aortic valve disease reflect differential fibro-calcific progression.
Prabutzki P, Wölk M, Böttner J, Ni Z, Werner S, Thiele H, Schiller J, Büttner P, Schlotter F, Fedorova M
Nat Commun. 2025 Jun 3;16(1):5163. doi: 10.1038/s41467-025-60411-2.PMID: 40461477
- The ferroptosis mediator ACSL4 fails to prevent disease progression in mouse models of MASLD.
Angendohr C, Koppe C, Herebian D, Schneider AT, Keysberg L, Singer MT, Gilljam J, Dille MA, Bode JG, Doll S, Conrad M, Vucur M,Luedde T.
Hepatol Commun. 2025 May 16;9(6):e0684. doi: 10.1097/HC9.0000000000000684. eCollection 2025 Jun 1.PMID: 40377498
- Activation of lysosomal iron triggers ferroptosis in cancer.
Cañeque T, Baron L, Müller S, Carmona A, Colombeau L, Versini A, Solier S, Gaillet C, Sindikubwabo F, Sampaio JL, Sabatier M, Mishima E, Picard-Bernes A, Syx L, Servant N, Lombard B, Loew D, Zheng J, Proneth B, Thoidingjam LK, Grimaud L, Fraser CS, Szylo KJ, Der Kazarian E, Bonnet C, Charafe-Jauffret E, Ginestier C, Santofimia-Castaño P, Estaras M, Dusetti N, Iovanna JL, Cunha AS, Pittau G, Hammel P, Tzanis D, Bonvalot S, Watson S, Gandon V, Upadhyay A, Pratt DA, Freitas FP, Friedmann Angeli JP, Stockwell BR, Conrad M, Ubellacker JM, Rodriguez R.
Nature. 2025 Jun;642(8067):492-500. doi: 10.1038/s41586-025-08974-4. Epub 2025 May 7.PMID: 40335696
- ALDH7A1 protects against ferroptosis by generating membrane NADH and regulating FSP1.
Yang JS, Morris AJ, Kamizaki K, Chen J, Stark J, Oldham WM, Nakamura T, Mishima E, Loscalzo J, Minami Y, Conrad M, Henry WS, Hsu VW.
Cell. 2025 May 15;188(10):2569-2585.e20. doi: 10.1016/j.cell.2025.03.019. Epub 2025 Apr 14.PMID: 40233740
- An atlas of ferroptosis-induced secretomes.Yapici FI, Seidel E, Dahlhaus A, Weber J, Schmidt C, de Britto Chaves Filho A, Yang M, Nenchova M, Güngör E, Stroh J, Kotouza I, Beck J, Abdallah AT, Lackmann JW, Bebber CM, Androulidaki A, Kreuzaler P, Schulze A, Frezza C, von Karstedt S.
Cell Death Differ. 2025 Apr 25. doi: 10.1038/s41418-025-01517-4. Online ahead of print.PMID: 40281125
- N-acetyl-l-cysteine averts ferroptosis by fostering glutathione peroxidase 4.
Zheng J, Zhang W, Ito J, Henkelmann B, Xu C, Mishima E,Conrad M
Cell Chem Biol. 2025 May 15;32(5):767-775.e5. doi: 10.1016/j.chembiol.2025.04.002. Epub 2025 Apr 30.PMID: 40311609
- Hepatocyte Toll-like receptors contribute to the hepcidin inflammatory response to pathogens and pathogen-derived ligands.
Bonitz K, Colucci S, Qiu R, Altamura S, Sparla R, Mudder K, Zimmermann S, Hentze MW, Muckenthaler MU, Marques O.
Hemasphere. 2025 Apr 3;9(4):e70096. doi: 10.1002/hem3.70096. eCollection 2025 Apr.PMID: 40182015
- Ferroptosis: when metabolism meets cell death.Physiol Rev. 2025 Apr 1;105(2):651-706. doi: 10.1152/physrev.00031.2024. Epub 2024 Dec 11.PMID: 39661331 Free article. Review.
- An unexpected player in organ tropism: aspartate functions as signalling molecule to drive lung metastasis.
Vogel FCE, Schulze A.
Signal Transduct Target Ther. 2025 Mar 21;10(1):95. doi: 10.1038/s41392-025-02189-9.PMID: 40113746 Free PMC article. No abstract available. - Ferroptosis spreads to neighboring cells via plasma membrane contact
Roeck BF, Lotfipour Nasudivar S, Vorndran MRH, Schueller L, Yapici FI, Rübsam M, von Karstedt S, Niessen CM, Garcia-Saez AJ.
Nat Commun. 2025 Mar 26;16(1):2951. doi: 10.1038/s41467-025-58175-w. PMID: 40140422
- Interactions of Fatty Acid and Cholesterol Metabolism with Cellular Stress Response Pathways in Cancer.
Winkelkotte AM, Al-Shami K, Chaves-Filho AB, Vogel FCE, Schulze A.
Cold Spring Harb Perspect Med. 2025 Mar 3;15(3):a041548. doi: 10.1101/cshperspect.a041548.PMID: 38951029 Review.
- Chronic intermittent fasting impairs β cell maturation and function in adolescent mice.
Matta L, Weber P, Erener S, Walth-Hummel A, Hass D, Bühler LK, Klepac K, Szendroedi J, Guerra J, Rohm M, Sterr M, Lickert H, Bartelt A, Herzig S.
Cell Rep. 2025 Feb 25;44(2):115225. doi: 10.1016/j.celrep.2024.115225. Epub 2025 Jan 18. PMID: 39827461
- Control of Systemic Iron Homeostasis: Insights Gained from Studying Mouse Models.Altamura S, Muckenthaler MU.
Adv Exp Med Biol. 2025;1480:103-118. doi: 10.1007/978-3-031-92033-2_8.PMID: 40603787
- Splenic TNF-α signaling potentiates the innate-to-adaptive transition of antiviral NK cells.
Mujal AM, Owyong M, Santosa EK, Sauter JC, Grassmann S, Pedde AM, Meiser P, Wingert CK, Pujol M, Buchholz VR, Lau CM, Böttcher JP, Sun JC.
Immunity. 2025 Mar 11;58(3):585-600.e6. doi: 10.1016/j.immuni.2025.02.012. Epub 2025 Feb 28.
- Targeting aldolase A in hepatocellular carcinoma leads to imbalanced glycolysis and energy stress due to uncontrolled FBP accumulation.Nat Metab. 2025 Feb;7(2):348-366. doi: 10.1038/s42255-024-01201-w. Epub 2025 Jan 20. PMID: 39833612
- Tissue-colonizing disseminated tumor cells secrete prostaglandin E2 to promote NK cell dysfunction and evade anti-metastatic immunityCell Rep. 2024 Nov 26;43(11):114855. doi: 10.1016/j.celrep.2024.114855. Epub 2024 Nov 13.PMID: 39541209
- PRDX6 contributes to selenocysteine metabolism and ferroptosis resistance.
Chen Z, Inague A, Kaushal K, Fazeli G, Schilling D, Xavier da Silva TN, Dos Santos AF, Cheytan T, Freitas FP, Yildiz U, Viviani LG, Lima RS, Pinz MP, Medeiros I, Iijima TS, Alegria TGP, Pereira da Silva R, Diniz LR, Weinzweig S, Klein-Seetharaman J, Trumpp A, Mañas A, Hondal R, Bartenhagen C, Fischer M, Shimada BK, Seale LA, Chillon TS, Fabiano M, Schomburg L, Schweizer U, Netto LE, Meotti FC, Dick TP, Alborzinia H, Miyamoto S, Friedmann Angeli JP.
Mol Cell. 2024 Dec 5;84(23):4645-4659.e9. doi: 10.1016/j.molcel.2024.10.027. Epub 2024 Nov 14.
- Contribution of individual phospholipase A2 enzymes to the cleavage of oxidized phospholipids in human blood plasma.
Jokesch P, Oskolkova O, Fedorova M, Gesslbauer B, Bochkov V.
J Lipid Res. 2025 Feb;66(2):100742. doi: 10.1016/j.jlr.2025.100742. Epub 2025 Jan 6.
