Publications

Emergence of (hydro)persulfides as suppressors of lipid peroxidation and ferroptotic cell death.

Wu Z, Barayeu U, Schilling D, Dick TP, Pratt DA.

Curr Opin Chem Biol. 2023 Oct;76:102353. doi: 10.1016/j.cbpa.2023.102353. Epub 2023 Jun 24. PMID: 37356334 Review.

Calcium as a master regulator of ferroptosis and other types of regulated necrosis.

Pedrera L, Ros U, García-Sáez AJ.

Cell Calcium. 2023 Sep;114:102778. doi: 10.1016/j.ceca.2023.102778. Epub 2023 Jun 19. PMID: 37356350 Review.

Methane formation driven by light and heat prior to the origin of life and beyond.

Ernst L, Barayeu U, Hädeler J, Dick TP, Klatt JM, Keppler F, Rebelein JG.
Nat Commun. 2023 Aug 1;14(1):4364. doi: 10.1038/s41467-023-39917-0. PMID: 37528079 Free PMC article.

Endocrine communication of endoplasmic reticulum stress.

Gómez AM, Bartelt A.

Bioessays. 2023 Aug;45(8):e2300093. doi: 10.1002/bies.202300093. Epub 2023 Jun 15. PMID: 37318317 No abstract available.

LRP8-mediated selenocysteine uptake is a targetable vulnerability in MYCN-amplified neuroblastoma.

Alborzinia H, Chen Z, Yildiz U, Freitas FP, Vogel FCE, Varga JP, Batani J, Bartenhagen C, Schmitz W, Büchel G, Michalke B, Zheng J, Meierjohann S, Girardi E, Espinet E, Flórez AF, Dos Santos AF, Aroua N, Cheytan T, Haenlin J, Schlicker L, Xavier da Silva TN, Przybylla A, Zeisberger P, Superti-Furga G, Eilers M, Conrad M, Fabiano M, Schweizer U, Fischer M, Schulze A, Trumpp A, Friedmann Angeli JP.

EMBO Mol Med. 2023 Jul 12:e18014. doi: 10.15252/emmm.202318014. Online ahead of print. PMID: 37435859 Free article.

A distinct stimulatory cDC1 subpopulation amplifies CD8+ T cell responses in tumors for protective anti-cancer immunity.

Meiser P, Knolle MA, Hirschberger A, de Almeida GP, Bayerl F, Lacher S, Pedde AM, Flommersfeld S, Hönninger J, Stark L, Stögbauer F, Anton M, Wirth M, Wohlleber D, Steiger K, Buchholz VR, Wollenberg B, Zielinski CE, Braren R, Rueckert D, Knolle PA, Kaissis G, Böttcher JP.

Cancer Cell. 2023 Jul 11:S1535-6108(23)00218-0. doi: 10.1016/j.ccell.2023.06.008. Online ahead of print. PMID: 37451271 Free article.

Phase separation of FSP1 promotes ferroptosis.

Nakamura T, Hipp C, Santos Dias Mourão A, Borggräfe J, Aldrovandi M, Henkelmann B, Wanninger J, Mishima E, Lytton E, Emler D, Proneth B, Sattler M, Conrad M.

Nature. 2023 Jul;619(7969):371-377. doi: 10.1038/s41586-023-06255-6. Epub 2023 Jun 28.PMID: 37380771

Cholesterol atlas of tumor microenvironment provides route to improved CAR-T therapy.

Chaves-Filho AB, Schulze A.

Cancer Cell. 2023 Jul 10;41(7):1204-1206. doi: 10.1016/j.ccell.2023.05.013. Epub 2023 May 26. PMID: 37244258

The influence of alkylating agents on sulfur-sulfur bonds in per- and polysulfides.

Schilling D, Ditrói T, Barayeu U, Jurányi EP, Nagy P, Dick TP.

Curr Opin Chem Biol. 2023 Jul 18;76:102368. doi: 10.1016/j.cbpa.2023.102368. Online ahead of print. PMID: 37473483 Review.

DHODH inhibitors sensitize to ferroptosis by FSP1 inhibition.

Mishima E, Nakamura T, Zheng J, Zhang W, Mourão ASD, Sennhenn P, Conrad M.

Nature. 2023 Jul;619(7968):E9-E18. doi: 10.1038/s41586-023-06269-0. Epub 2023 Jul 5.PMID: 37407687

Hepatic inflammatory responses in liver fibrosis.

Hammerich L, Tacke F.

Nat Rev Gastroenterol Hepatol. 2023 Jul 3. doi: 10.1038/s41575-023-00807-x. Online ahead of print. PMID: 37400694 Review.

Low level of antioxidant capacity biomarkers but not target overexpression predicts vulnerability to ROS-inducing drugs.

Samarin J, Fabrowski P, Kurilov R, Nuskova H, Hummel-Eisenbeiss J, Pink H, Li N, Weru V, Alborzinia H, Yildiz U, Grob L, Taubert M, Czech M, Morgen M, Brandstädter C, Becker K, Mao L, Jayavelu AK, Goncalves A, Uhrig U, Seiler J, Lyu Y, Diederichs S, Klingmüller U, Muckenthaler M, Kopp-Schneider A, Teleman A, Miller AK, Gunkel N.

Redox Biol. 2023 Jun;62:102639. doi: 10.1016/j.redox.2023.102639. Epub 2023 Feb 23. PMID: 36958250 Free PMC article.

Tumor-derived prostaglandin E2 programs cDC1 dysfunction to impair intratumoral orchestration of anti-cancer T cell responses.

Bayerl F, Meiser P, Donakonda S, Hirschberger A, Lacher SB, Pedde AM, Hermann CD, Elewaut A, Knolle M, Ramsauer L, Rudolph TJ, Grassmann S, Öllinger R, Kirchhammer N, Trefny M, Anton M, Wohlleber D, Höchst B, Zaremba A, Krüger A, Rad R, Obenauf AC, Schadendorf D, Zippelius A, Buchholz VR, Schraml BU, Böttcher JP.

Immunity. 2023 Jun 13;56(6):1341-1358.e11. doi: 10.1016/j.immuni.2023.05.011. PMID: 37315536 Free article.

Diverse biological functions of vitamin K: from coagulation to ferroptosis.

Mishima E, Wahida A, Seibt T, Conrad M.

Nat Metab. 2023 Jun;5(6):924-932. doi: 10.1038/s42255-023-00821-y. Epub 2023 Jun 19. PMID: 37337123 Review.

Sublethal necroptosis signaling promotes inflammation and liver cancer.

Vucur M, Ghallab A, Schneider AT, Adili A, Cheng M, Castoldi M, Singer MT, Büttner V, Keysberg LS, Küsgens L, Kohlhepp M, Görg B, Gallage S, Barragan Avila JE, Unger K, Kordes C, Leblond AL, Albrecht W, Loosen SH, Lohr C, Jördens MS, Babler A, Hayat S, Schumacher D, Koenen MT, Govaere O, Boekschoten MV, Jörs S, Villacorta-Martin C, Mazzaferro V, Llovet JM, Weiskirchen R, Kather JN, Starlinger P, Trauner M, Luedde M, Heij LR, Neumann UP, Keitel V, Bode JG, Schneider RK, Tacke F, Levkau B, Lammers T, Fluegen G, Alexandrov T, Collins AL, Nelson G, Oakley F, Mann DA, Roderburg C, Longerich T, Weber A, Villanueva A, Samson AL, Murphy JM, Kramann R, Geisler F, Costa IG, Hengstler JG, Heikenwalder M, Luedde T.

Immunity. 2023 Jun 12:S1074-7613(23)00234-0. doi: 10.1016/j.immuni.2023.05.017. Online ahead of print. PMID: 37329888 Free article.

Ferroptosis: mechanisms and implications for cancer development and therapy response.

Dos Santos AF, Fazeli G, Xavier da Silva TN, Friedmann Angeli JP.

Trends Cell Biol. 2023 May 23:S0962-8924(23)00079-X. doi: 10.1016/j.tcb.2023.04.005. Online ahead of print. PMID: 37230924 Review.

vPIF-1 is an insulin-like antiferroptotic viral peptide.

Belavgeni A, Maremonti F, Tonnus W, Stadtmüller M, Gavali S, Mallais M, Flade K, Brucker A, Becker JN, Beer K, Tmava M, Stumpf J, Gembardt F, Hugo C, Giacca M, Hale BG, Perakakis N, Sha W, Pratt DA, Schally AV, Bornstein SR, Linkermann A.

Proc Natl Acad Sci U S A. 2023 May 23;120(21):e2300320120. doi: 10.1073/pnas.2300320120. Epub 2023 May 15. PMID: 37186845 Free PMC article.

Consensus Statement on the definition and classification of metabolic hyperferritinaemia.

Valenti L, Corradini E, Adams LA, Aigner E, Alqahtani S, Arrese M, Bardou-Jacquet E, Bugianesi E, Fernandez-Real JM, Girelli D, Hagström H, Henninger B, Kowdley K, Ligabue G, McClain D, Lainé F, Miyanishi K, Muckenthaler MU, Pagani A, Pedrotti P, Pietrangelo A, Prati D, Ryan JD, Silvestri L, Spearman CW, Stål P, Tsochatzis EA, Vinchi F, Zheng MH, Zoller H.

Nat Rev Endocrinol. 2023 May;19(5):299-310. doi: 10.1038/s41574-023-00807-6. Epub 2023 Feb 17. PMID: 36805052 Free PMC article. Review.

Resolving 31 colors on a standard 3-laser full spectrum flow cytometer for immune monitoring of human blood samples.

Hammerich L, Shevchenko Y, Knorr J, Werner W, Bruneau A, Tacke F.

Cytometry B Clin Cytom. 2023 May 20. doi: 10.1002/cyto.b.22126. Online ahead of print. PMID: 37209003

The role of proteasome activators PA28αβ and PA200 in brown adipocyte differentiation and function.

Koçberber Z, Willemsen N, Bartelt A.
Front Endocrinol (Lausanne). 2023 May 2;14:1176733. doi: 10.3389/fendo.2023.1176733. eCollection 2023. PMID: 37201100 Free PMC article.

3-Mercaptopyruvate sulfur transferase is a protein persulfidase.

Pedre B, Talwar D, Barayeu U, Schilling D, Luzarowski M, Sokolowski M, Glatt S, Dick TP.

Nat Chem Biol. 2023 Apr;19(4):507-517. doi: 10.1038/s41589-022-01244-8. Epub 2023 Feb 2. PMID: 36732619 Free PMC article.

Molecular characterization of AIFM2/FSP1 inhibition by iFSP1-like molecules.

Xavier da Silva TN, Schulte C, Alves AN, Maric HM, Friedmann Angeli JP.

Cell Death Dis. 2023 Apr 21;14(4):281. doi: 10.1038/s41419-023-05787-z. PMID: 37080964 Free PMC article.

Triglyceride cycling enables modification of stored fatty acids.

Wunderling K, Zurkovic J, Zink F, Kuerschner L, Thiele C.

Nat Metab. 2023 Apr;5(4):699-709. doi: 10.1038/s42255-023-00769-z. Epub 2023 Apr 3. PMID: 37012495 Free PMC article.

Analytical Toolbox to Unlock the Diversity of Oxidized Lipids.

Wölk M, Prabutzki P, Fedorova M.

Acc Chem Res. 2023 Apr 4;56(7):835-845. doi: 10.1021/acs.accounts.2c00842. Epub 2023 Mar 21. PMID: 36943749

Editorial to the Special Issue "Homeostasis: Metals and Cellular Redox and Immunity Status".

Michalke B, Venkataramani V.

Int J Mol Sci. 2023 Mar 3;24(5):4889. doi: 10.3390/ijms24054889. PMID: 36902319 Free PMC article.

Immunological consequences of arsenic trioxide-induced necrosis.

Gavali S, Tonnus W, Linkermann A.
Cell Mol Immunol. 2023 Mar;20(3):308-309. doi: 10.1038/s41423-023-00976-4. Epub 2023 Jan 25. PMID: 36693921 Free PMC article. No abstract available.

Hepatic Stellate Cells: Dictating Outcome in Nonalcoholic Fatty Liver Disease.

Wiering L, Subramanian P, Hammerich L.

Cell Mol Gastroenterol Hepatol. 2023;15(6):1277-1292. doi: 10.1016/j.jcmgh.2023.02.010. Epub 2023 Feb 23. PMID: 36828280 Free PMC article. Review.

Guiding the choice of informatics software and tools for lipidomics research applications.

Ni Z, Wölk M, Jukes G, Mendivelso Espinosa K, Ahrends R, Aimo L, Alvarez-Jarreta J, Andrews S, Andrews R, Bridge A, Clair GC, Conroy MJ, Fahy E, Gaud C, Goracci L, Hartler J, Hoffmann N, Kopczyinki D, Korf A, Lopez-Clavijo AF, Malik A, Ackerman JM, Molenaar MR, O’Donovan C, Pluskal T, Shevchenko A, Slenter D, Siuzdak G, Kutmon M, Tsugawa H, Willighagen EL, Xia J, O’Donnell VB, Fedorova M.

Nat Methods. 2023 Feb;20(2):193-204. doi: 10.1038/s41592-022-01710-0. Epub 2022 Dec 21. PMID: 36543939 Free PMC article. Review.

Guidelines for visualization and analysis of DC in tissues using multiparameter fluorescence microscopy imaging methods.

Bayerl F, Bejarano DA, Bertacchi G, Doffin AC, Gobbini E, Hubert M, Li L, Meiser P, Pedde AM, Posch W, Rupp L, Schlitzer A, Schmitz M, Schraml BU, Uderhardt S, Valladeau-Guilemond J, Wilflingseder D, Zaderer V, Böttcher JP.

Eur J Immunol. 2023 Jan 9:e2249923. doi: 10.1002/eji.202249923. Online ahead of print. PMID: 36623939

Hydropersulfides inhibit lipid peroxidation and ferroptosis by scavenging radicals.

Barayeu U, Schilling D, Eid M, Xavier da Silva TN, Schlicker L, Mitreska N, Zapp C, Gräter F, Miller AK, Kappl R, Schulze A, Friedmann Angeli JP, Dick TP.

Nat Chem Biol. 2023 Jan;19(1):28-37. doi: 10.1038/s41589-022-01145-w. Epub 2022 Sep 15. PMID: 36109647 Free PMC article.

Mitochondrial ferritin expression in human macrophages is facilitated by thrombin-mediated cleavage under hypoxia.

Fuhrmann DC, Becker S, Brüne B.

FEBS Lett. 2023 Jan;597(2):276-287. doi: 10.1002/1873-3468.14545. Epub 2022 Dec 1. PMID: 36416578

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