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2026

A fin-loop-like structure in GPX4 underlies neuroprotection from ferroptosis.

Lorenz SM, Wahida A, Bostock MJ, Seibt T, Santos Dias Mourão A, Levkina A, Trümbach D, Soudy M, Emler D, Rothammer N, Woo MS, Sonner JK, Novikova M, Henkelmann B, Aldrovandi M, Kaemena DF, Mishima E, Vermonden P, Zong Z, Chen D, Nakamura T, Ito J, Doll S, Proneth B, Bürkle E, Rizzollo F, Escamilla Ayala A, Napolitano V, Kolonko-Adamska M, Gaussmann S, Merl-Pham J, Hauck S, Pertek A, Orschmann T, van San E, Vanden Berghe T, Hass D, Maida A, Frenz JM, Pedrera L, Dolga A, Kraiger M, Hrabé de Angelis M, Fuchs H, Ebert G, Lenberg J, Friedman J, Scale C, Agostinis P, Zimprich A, Vogt-Weisenhorn D, Garrett L, Hölter SM, Wurst W, Glaab E, Lewerenz J, Popper B, Sieben C, Steinacker P, Zischka H, Garcia-Saez AJ, Tietze A, Ramesh SK, Ayton S, Vincendeau M, Friese MA, Wigby K, Sattler M, Mann M, Ingold I, Jayavelu AK, Popowicz GM, Conrad M.

Cell. 2026 Jan 8;189(1):287-306.e35. doi: 10.1016/j.cell.2025.11.014. Epub 2025 Dec 4. PMID: 41349546
Targeting FSP1 triggers ferroptosis in lung cancer.

Wu K, Vaughan AJ, Bossowski JP, Hao Y, Ziogou A, Kim SM, Kim TH, Nakamura MN, Pillai R, Mancini M, Rajalingam S, Han M, Nakamura T, Wang L, Chung S, Simeone D, Shackelford D, Kang YP, Conrad M, Papagiannakopoulos T.

Nature. 2026 Jan;649(8096):487-495. doi: 10.1038/s41586-025-09710-8. Epub 2025 Nov 5. PMID: 41193800 Free PMC article.
Lymph node environment drives FSP1 targetability in metastasizing melanoma.

Palma M, Chaufan M, Breuer CB, Müller S, Sabatier M, Fraser CS, Szylo KJ, Yavari M, Carmona A, Kaur M, Melo LMN, Cansiz F, Monge-Lorenzo J, Flores M, Mishima E, Nakamura T, Proneth B, Labrado M, Liang Y, Cayting N, Zheng L, Cañeque T, Colombeau L, Wahida A, Friedmann Angeli JP, Tasdogan A, Hui S, Rodriguez R, Conrad M, Reticker-Flynn NE, Ubellacker JM.

Nature. 2026 Jan;649(8096):477-486. doi: 10.1038/s41586-025-09709-1. Epub 2025 Nov 5. PMID: 41193799 Free PMC article.

2025

Iron raider: Tumors in the bone marrow.

Zheng J, Conrad M.

Cell. 2025 Oct 30;188(22):6107-6108. doi: 10.1016/j.cell.2025.09.028.PMID: 41172979
Multiple oestradiol functions inhibit ferroptosis and acute kidney injury.

Tonnus W, Maremonti F, Gavali S, Schlecht MN, Gembardt F, Belavgeni A, Leinung N, Flade K, Bethe N, Traikov S, Haag A, Schilling D, Penkov S, Mallais M, Gaillet C, Meyer C, Katebi M, Ray A, Gerhardt LMS, Brucker A, Becker JN, Tmava M, Schlicker L, Schulze A, Himmerkus N, Shevchenko A, Peitzsch M, Barayeu U, Nasi S, Putz J, Korach KS, Neugarten J, Golestaneh L, Hugo C, Becker JU, Weinberg JM, Lorenz S, Proneth B, Conrad M, Wolf E, Plietker B, Rodriguez R, Pratt DA, Dick TP, Fedorova M, Bornstein SR, Linkermann A.

Nature. 2025 Sep;645(8082):1011-1019. doi: 10.1038/s41586-025-09389-x. Epub 2025 Aug 13.PMID: 40804518
Recommendations for robust and reproducible research on ferroptosis.

Mishima E, Nakamura T, Doll S, Proneth B, Fedorova M, Pratt DA, Friedmann Angeli JP, Dixon SJ, Wahida A, Conrad M.

Nat Rev Mol Cell Biol. 2025 Aug;26(8):615-630. doi: 10.1038/s41580-025-00843-2. Epub 2025 Apr 9. PMID: 40204928
Aberrant Mitochondrial Metabolism in Alzheimer’s Disease Links Energy Stress with Ferroptosis.

Alves F, Lane D, Wahida A, Jakaria M, Kalinowski P, Southon A, Belaidi AA, Samperi-Esteve T, Nguyen TPM, Lei P, Krueger M, Mueller S, Conrad M, Agarwal P, Leurgans SE, Schneider J, Bush AI, Ayton S.

Adv Sci (Weinh). 2025 Jul 8:e04175. doi: 10.1002/advs.202504175. Online ahead of print.PMID: 40625200
Loss of apolipoprotein E contributes to inflammatory macrophage activation and ferroptosis in NSAID-exacerbated respiratory disease.

Schmiz G, Haimerl P, Ram I, Kulagin M, Spitzlberger B, Henkel FDR, Hartung F, Schindela S, Rao Z, Koeberle A, Schmidt-Weber CB, Chaker AM, Lechner A, Esser-von Bieren J.

J Allergy Clin Immunol. 2025 Jun 19:S0091-6749(25)00652-9. doi: 10.1016/j.jaci.2025.06.010. Online ahead of print.PMID: 40543901
The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis.

Woo MS, Brand J, Bal LC, Moritz M, Walkenhorst M, Vieira V, Ipenberg I, Rothammer N, Wang M, Dogan B, Loreth D, Mayer C, Nagel D, Wagner I, Pfeffer LK, Landgraf P, van Ham M, Mattern KM, Winschel I, Frantz N, Sonner JK, Grosshans HK, Miguela A, Bauer S, Meurs N, Müller A, Binkle-Ladisch L, Salinas G, Jänsch L, Dieterich DC, Riedner M, Krüger E, Heppner FL, Glatzel M, Puelles VG, Engler JB, Nyengaard JR, Misgeld T, Kerschensteiner M, Merkler D, Meyer-Schwesinger C, Friese MA.

Cell. 2025 Jun 13:S0092-8674(25)00616-6. doi: 10.1016/j.cell.2025.05.029. Online ahead of print.PMID: 40532699
Sex-specific lipidomic signatures in aortic valve disease reflect differential fibro-calcific progression.

Prabutzki P, Wölk M, Böttner J, Ni Z, Werner S, Thiele H, Schiller J, Büttner P, Schlotter F, Fedorova M

Nat Commun. 2025 Jun 3;16(1):5163. doi: 10.1038/s41467-025-60411-2.PMID: 40461477
The ferroptosis mediator ACSL4 fails to prevent disease progression in mouse models of MASLD.

Angendohr C, Koppe C, Herebian D, Schneider AT, Keysberg L, Singer MT, Gilljam J, Dille MA, Bode JG, Doll S, Conrad M, Vucur M,Luedde T.

Hepatol Commun. 2025 May 16;9(6):e0684. doi: 10.1097/HC9.0000000000000684. eCollection 2025 Jun 1.PMID: 40377498
Activation of lysosomal iron triggers ferroptosis in cancer.

Cañeque T, Baron L, Müller S, Carmona A, Colombeau L, Versini A, Solier S, Gaillet C, Sindikubwabo F, Sampaio JL, Sabatier M, Mishima E, Picard-Bernes A, Syx L, Servant N, Lombard B, Loew D, Zheng J, Proneth B, Thoidingjam LK, Grimaud L, Fraser CS, Szylo KJ, Der Kazarian E, Bonnet C, Charafe-Jauffret E, Ginestier C, Santofimia-Castaño P, Estaras M, Dusetti N, Iovanna JL, Cunha AS, Pittau G, Hammel P, Tzanis D, Bonvalot S, Watson S, Gandon V, Upadhyay A, Pratt DA, Freitas FP, Friedmann Angeli JP, Stockwell BR, Conrad M, Ubellacker JM, Rodriguez R.

Nature. 2025 Jun;642(8067):492-500. doi: 10.1038/s41586-025-08974-4. Epub 2025 May 7.PMID: 40335696
ALDH7A1 protects against ferroptosis by generating membrane NADH and regulating FSP1.

Yang JS, Morris AJ, Kamizaki K, Chen J, Stark J, Oldham WM, Nakamura T, Mishima E, Loscalzo J, Minami Y, Conrad M, Henry WS, Hsu VW.

Cell. 2025 May 15;188(10):2569-2585.e20. doi: 10.1016/j.cell.2025.03.019. Epub 2025 Apr 14.PMID: 40233740
An atlas of ferroptosis-induced secretomes.
Yapici FI, Seidel E, Dahlhaus A, Weber J, Schmidt C, de Britto Chaves Filho A, Yang M, Nenchova M, Güngör E, Stroh J, Kotouza I, Beck J, Abdallah AT, Lackmann JW, Bebber CM, Androulidaki A, Kreuzaler P, Schulze A, Frezza C, von Karstedt S.

Cell Death Differ. 2025 Apr 25. doi: 10.1038/s41418-025-01517-4. Online ahead of print.PMID: 40281125
N-acetyl-l-cysteine averts ferroptosis by fostering glutathione peroxidase 4.

Zheng J, Zhang W, Ito J, Henkelmann B, Xu C, Mishima E,Conrad M

Cell Chem Biol. 2025 May 15;32(5):767-775.e5. doi: 10.1016/j.chembiol.2025.04.002. Epub 2025 Apr 30.PMID: 40311609
Hepatocyte Toll-like receptors contribute to the hepcidin inflammatory response to pathogens and pathogen-derived ligands.

Bonitz K, Colucci S, Qiu R, Altamura S, Sparla R, Mudder K, Zimmermann S, Hentze MW, Muckenthaler MU, Marques O.

Hemasphere. 2025 Apr 3;9(4):e70096. doi: 10.1002/hem3.70096. eCollection 2025 Apr.PMID: 40182015
Ferroptosis: when metabolism meets cell death.

Zheng J, Conrad M.

Physiol Rev. 2025 Apr 1;105(2):651-706. doi: 10.1152/physrev.00031.2024. Epub 2024 Dec 11.PMID: 39661331 Free article. Review.
An unexpected player in organ tropism: aspartate functions as signalling molecule to drive lung metastasis.

Vogel FCE, Schulze A.

Signal Transduct Target Ther. 2025 Mar 21;10(1):95. doi: 10.1038/s41392-025-02189-9.PMID: 40113746 Free PMC article. No abstract available.
Ferroptosis spreads to neighboring cells via plasma membrane contact

Roeck BF, Lotfipour Nasudivar S, Vorndran MRH, Schueller L, Yapici FI, Rübsam M, von Karstedt S, Niessen CM, Garcia-Saez AJ.

Nat Commun. 2025 Mar 26;16(1):2951. doi: 10.1038/s41467-025-58175-w. PMID: 40140422
Interactions of Fatty Acid and Cholesterol Metabolism with Cellular Stress Response Pathways in Cancer.

Winkelkotte AM, Al-Shami K, Chaves-Filho AB, Vogel FCE, Schulze A.

Cold Spring Harb Perspect Med. 2025 Mar 3;15(3):a041548. doi: 10.1101/cshperspect.a041548.PMID: 38951029 Review.
Chronic intermittent fasting impairs β cell maturation and function in adolescent mice.

Matta L, Weber P, Erener S, Walth-Hummel A, Hass D, Bühler LK, Klepac K, Szendroedi J, Guerra J, Rohm M, Sterr M, Lickert H, Bartelt A, Herzig S.

Cell Rep. 2025 Feb 25;44(2):115225. doi: 10.1016/j.celrep.2024.115225. Epub 2025 Jan 18. PMID: 39827461
Control of Systemic Iron Homeostasis: Insights Gained from Studying Mouse Models.
Altamura S, Muckenthaler MU.

Adv Exp Med Biol. 2025;1480:103-118. doi: 10.1007/978-3-031-92033-2_8.PMID: 40603787
Splenic TNF-α signaling potentiates the innate-to-adaptive transition of antiviral NK cells.

Mujal AM, Owyong M, Santosa EK, Sauter JC, Grassmann S, Pedde AM, Meiser P, Wingert CK, Pujol M, Buchholz VR, Lau CM, Böttcher JP, Sun JC.

Immunity. 2025 Mar 11;58(3):585-600.e6. doi: 10.1016/j.immuni.2025.02.012. Epub 2025 Feb 28.
Targeting aldolase A in hepatocellular carcinoma leads to imbalanced glycolysis and energy stress due to uncontrolled FBP accumulation.

Snaebjornsson MT, Poeller P, Komkova D, Röhrig F, Schlicker L, Winkelkotte AM, Chaves-Filho AB, Al-Shami KM, Caballero CD, Koltsaki I, Vogel FCE, Frias-Soler RC, Rudalska R, Schwarz JD, Wolf E, Dauch D, Steuer R, Schulze A.

Nat Metab. 2025 Feb;7(2):348-366. doi: 10.1038/s42255-024-01201-w. Epub 2025 Jan 20. PMID: 39833612
Tissue-colonizing disseminated tumor cells secrete prostaglandin E2 to promote NK cell dysfunction and evade anti-metastatic immunity

Pedde AM, Kim H, Donakonda S, Baumann T, Bayerl F, Meiser P, Hirschberger A, Klement C, Grassmann S, Öllinger R, Hüser N, Hartmann D, Laschinger M, Trapani JA, Zippelius A, Bald T, Wiedemann GM, Rad R, Sun JC, Höchst B, Böttcher JP.

Cell Rep. 2024 Nov 26;43(11):114855. doi: 10.1016/j.celrep.2024.114855. Epub 2024 Nov 13.PMID: 39541209
PRDX6 contributes to selenocysteine metabolism and ferroptosis resistance.

Chen Z, Inague A, Kaushal K, Fazeli G, Schilling D, Xavier da Silva TN, Dos Santos AF, Cheytan T, Freitas FP, Yildiz U, Viviani LG, Lima RS, Pinz MP, Medeiros I, Iijima TS, Alegria TGP, Pereira da Silva R, Diniz LR, Weinzweig S, Klein-Seetharaman J, Trumpp A, Mañas A, Hondal R, Bartenhagen C, Fischer M, Shimada BK, Seale LA, Chillon TS, Fabiano M, Schomburg L, Schweizer U, Netto LE, Meotti FC, Dick TP, Alborzinia H, Miyamoto S, Friedmann Angeli JP.

Mol Cell. 2024 Dec 5;84(23):4645-4659.e9. doi: 10.1016/j.molcel.2024.10.027. Epub 2024 Nov 14.
Contribution of individual phospholipase A2 enzymes to the cleavage of oxidized phospholipids in human blood plasma.

Jokesch P, Oskolkova O, Fedorova M, Gesslbauer B, Bochkov V.

J Lipid Res. 2025 Feb;66(2):100742. doi: 10.1016/j.jlr.2025.100742. Epub 2025 Jan 6.

2024

Iron-Induced Lipid Oxidation Alters Membrane Mechanics Favoring Permeabilization.
Lotfipour Nasudivar S, Pedrera L, García-Sáez AJ.

Langmuir. 2024 Nov 26;40(47):25061-25068. doi: 10.1021/acs.langmuir.4c03294. Epub 2024 Nov 12.PMID: 39532309
PRDX6 dictates ferroptosis sensitivity by directing cellular selenium utilization.

Ito J, Nakamura T, Toyama T, Chen D, Berndt C, Poschmann G, Mourão ASD, Doll S, Suzuki M, Zhang W, Zheng J, Trümbach D, Yamada N, Ono K, Yazaki M, Kawai Y, Arisawa M, Ohsaki Y, Shirakawa H, Wahida A, Proneth B, Saito Y, Nakagawa K, Mishima E*, Conrad M*
Mol Cell. 2024 Nov 5:S1097-2765(24)00868-2. doi: 10.1016/j.molcel.2024.10.028. Online ahead of print. (*equal contribution).
Calcium signals as regulators of ferroptosis in cancer

Ioana Stejerean-Todoran, Christine S. Gibhardt, Ivan Bogeski.

Cell Calcium 2024, 102966, DOI: 10.1016/j.ceca.2024.102966
Inflammation in a ferroptotic environment.
Wickert A, Schwantes A, Fuhrmann DC, Brüne B.

Front Pharmacol. 2024 Sep 20;15:1474285. doi: 10.3389/fphar.2024.1474285. eCollection 2024.PMID: 39372215
STING orchestrates the neuronal inflammatory stress response in multiple sclerosis

Woo MS, Mayer C, Binkle-Ladisch L, Sonner JK, Rosenkranz SC, Shaposhnykov A, Rothammer N, Tsvilovskyy V, Lorenz SM, Raich L, Bal LC, Vieira V, Wagner I, Bauer S, Glatzel M, Conrad M, Merkler D, Freichel M, Friese MA
Cell. 2024 Jun 7:S0092-8674(24)00576-2. doi: 10.1016/j.cell.2024.05.031. Online ahead of print.
Ferroptosis in Health and Disease

Carsten Berndt, Hamed Alborzinia, Vera Skafar Amen, Scott Aytone, Uladzimir Barayeu, Alexander Bartelt, Hülya Bayir, Christina M. Bebber, Kivanc Birsoym, Jan P. Böttcher, Simone Brabletz, Thomas Brabletz, Ashley R. Brown, Bernhard Brüne, Giorgia Bulli, Alix Bruneau, Quan Chent, Gina M. DeNicolau, Tobias P. Dick, Ayelén Distéfano, Scott Dixon, Jan Broder Engler, Julia Esser-von Bieren, Maria Fedorova, José Pedro Friedmann Angeli, Manuel A. Friese, Dominic C. Fuhrmann, Ana J. García-Sáez, Karolina Garbowicz, Magdalena Götz, Wei Guae, Linda Hammerich, Behrouz Hassannia, Xuejun Jiang, Aicha Jeridi, Jun Pyo Kang, Valerian E Kagan, David B. Konrad, Stefan Kotschi, Peng Lei, Marlene le-Tertre, Sima Lev, Deguang Liang, Andreas Linkermann, Carolin Lohr, Svenja Lorenz, Tom Lüdde, Axel Methner, Bernhard Michalkeau, Anna V. Milton, Junxia Min, Eikan Mishima, Sebastian Müller, Hozumi Motohashi, Martina Muckenthaler, Shohei Murakami, James A. Olzmann, Gabriela Pagnuss, Zijan Pan, Thales Papagiannakopoulos, Lohans Pedrera Puentes, Derek A. Pratt, Bettina Proneth, Lukas Ramsauer, Raphael Rodriguez, Yoshiro Saito, Felix Schmidt, Carina Schmitt, Almut Schulze, Annemarie Schwab, Anna Schwantes, Mariluz Soul, Benedikt Spitzlberger, Brent R. Stockwell, Leonie Thewes, Oliver Thorn-Seshold, Shinya Toyokuni, Wulf Tonnus, Andreas Trumpp, Peter Vandenabeele, Tom Vanden Berghe, Vivek Vikantaramani, Felix C. E. Vogel, Silvia von Karstedt, Fudi Wang, Frank Westermann, Michele Wölk, Katherine Wu, Xin Yang, Fan Yu, Yilong Zou, and Marcus Conrad

Redox Biology May 24
PGE2 inhibits TIL expansion by disrupting IL-2 signalling and mitochondrial function.

Morotti M, Grimm AJ, Hope HC, Arnaud M, Desbuisson M, Rayroux N, Barras D, Masid M, Murgues B, Chap BS, Ongaro M, Rota IA, Ronet C, Minasyan A, Chiffelle J, Lacher SB, Bobisse S, Murgues C, Ghisoni E, Ouchen K, Bou Mjahed R, Benedetti F, Abdellaoui N, Turrini R, Gannon PO, Zaman K, Mathevet P, Lelievre L, Crespo I, Conrad M, Verdeil G, Kandalaft LE, Dagher J, Corria-Osorio J, Doucey MA, Ho PC, Harari A, Vannini N, Böttcher JP, Dangaj Laniti D, Coukos G.

Nature. 2024 May;629(8011):426-434. doi: 10.1038/s41586-024-07352-w. Epub 2024 Apr 24. PMID: 38658764
PGE2 limits effector expansion of tumour-infiltrating stem-like CD8+ T cells.

Lacher SB, Dörr J, de Almeida GP, Hönninger J, Bayerl F, Hirschberger A, Pedde AM, Meiser P, Ramsauer L, Rudolph TJ, Spranger N, Morotti M, Grimm AJ, Jarosch S, Oner A, Gregor L, Lesch S, Michaelides S, Fertig L, Briukhovetska D, Majed L, Stock S, Busch DH, Buchholz VR, Knolle PA, Zehn D, Dangaj Laniti D, Kobold S, Böttcher JP.
Nature. 2024 May;629(8011):417-425. doi: 10.1038/s41586-024-07254-x. Epub 2024 Apr 24. PMID: 38658748 Free PMC article
Cardiac proteostasis in obesity and cardiovascular disease.

Guerra J, Matta L, Bartelt A.
Herz. 2024 Mar;49(2):118-123. doi: 10.1007/s00059-024-05233-6. Epub 2024 Feb 8. PMID: 38329532 Free PMC article. Review.
Treatment with siRNAs is commonly associated with GPX4 up-regulation and target knockdown-independent sensitization to ferroptosis.

von Mässenhausen A, Schlecht MN, Beer K, Maremonti F, Tonnus W, Belavgeni A, Gavali S, Flade K, Riley JS, Zamora Gonzalez N, Brucker A, Becker JN, Tmava M, Meyer C, Peitzsch M, Hugo C, Gembardt F, Angeli JPF, Bornstein SR, Tait SWG, Linkermann A.
Sci Adv. 2024 Mar 15;10(11):eadk7329. doi: 10.1126/sciadv.adk7329. Epub 2024 Mar 15. PMID: 38489367 Free PMC article.
A tangible method to assess native ferroptosis suppressor activity.

Nakamura T, Ito J, Mourão ASD, Wahida A, Nakagawa K, Mishima E, Conrad M.
Cell Rep Methods. 2024 Feb 23:100710. doi: 10.1016/j.crmeth.2024.100710. Online ahead of print. PMID: 38401540 Free article.
Tumor associated macrophages transfer ceruloplasmin mRNA to fibrosarcoma cells and protect them from ferroptosis.

Schwantes A, Wickert A, Becker S, Baer PC, Weigert A, Brüne B, Fuhrmann DC.
Redox Biol. 2024 Feb 17;71:103093. doi: 10.1016/j.redox.2024.103093. Online ahead of print. PMID: 38382185 Free PMC article.
7-Dehydrocholesterol is an endogenous suppressor of ferroptosis.

Freitas FP, Alborzinia H, Dos Santos AF, Nepachalovich P, Pedrera L, Zilka O, Inague A, Klein C, Aroua N, Kaushal K, Kast B, Lorenz SM, Kunz V, Nehring H, Xavier da Silva TN, Chen Z, Atici S, Doll SG, Schaefer EL, Ekpo I, Schmitz W, Horling A, Imming P, Miyamoto S, Wehman AM, Genaro-Mattos TC, Mirnics K, Kumar L, Klein-Seetharaman J, Meierjohann S, Weigand I, Kroiss M, Bornkamm GW, Gomes F, Netto LES, Sathian MB, Konrad DB, Covey DF, Michalke B, Bommert K, Bargou RC, Garcia-Saez A, Pratt DA, Fedorova M, Trumpp A, Conrad M, Friedmann Angeli JP.

Nature. 2024 Jan 31. doi: 10.1038/s41586-023-06878-9. Online ahead of print.PMID: 38297129
Lipids as mediators of cancer progression and metastasis.

Vogel FCE, Chaves-Filho AB, Schulze A.
Nat Cancer. 2024 Jan;5(1):16-29. doi: 10.1038/s43018-023-00702-z. Epub 2024 Jan 25. PMID: 38273023 Review.
Membrane Epilipidome-Lipid Modifications, Their Dynamics, and Functional Significance.

Penkov S, Fedorova M.
Cold Spring Harb Perspect Biol. 2024 Jan 22:a041417. doi: 10.1101/cshperspect.a041417. Online ahead of print. PMID: 38253416
Lipids as mediators of cancer progression and metastasis

Vogel FCE, Chaves-Filho AB, Schulze A.
Nat Cancer. 2024 Jan;5(1):16-29. doi: 10.1038/s43018-023-00702-z. Epub 2024 Jan 25.PMID: 38273023 Review.
Direct neuronal reprogramming of NDUFS4 patient cells identifies the unfolded protein response as a novel general reprogramming hurdle.

Sonsalla G, Malpartida AB, Riedemann T, Gusic M, Rusha E, Bulli G, Najas S, Janjic A, Hersbach BA, Smialowski P, Drukker M, Enard W, Prehn JHM, Prokisch H, Götz M, Masserdotti G.
Neuron. 2024 Jan 17:S0896-6273(23)00978-9. doi: 10.1016/j.neuron.2023.12.020. Online ahead of print. PMID: 38266647 Free article.

2023

Thiol starvation triggers melanoma state switching in an ATF4 and NRF2-dependent manner.

Meinert M, Jessen C, Hufnagel A, Kreß JKC, Burnworth M, Däubler T, Gallasch T, Xavier da Silva TN, Dos Santos AF, Ade CP, Schmitz W, Kneitz S, Friedmann Angeli JP, Meierjohann S.
Redox Biol. 2024 Apr;70:103011. doi: 10.1016/j.redox.2023.103011. Epub 2023 Dec 27. PMID: 38219574 Free PMC article.
Zika virus remodelled ER membranes contain proviral factors involved in redox and methylation pathways.

Denolly S, Stukalov A, Barayeu U, Rosinski AN, Kritsiligkou P, Joecks S, Dick TP, Pichlmair A, Bartenschlager R.
Nat Commun. 2023 Dec 5;14(1):8045. doi: 10.1038/s41467-023-43665-6. PMID: 38052817 Free PMC article.
Mechanistic Insights into Ferroptotic Cell Death in Pancreatic Islets.

Schepp F, Schubert U, Schmid J, Lehmann S, Latunde-Dada GO, Kose T, Steenblock C, Bornstein SR, Linkermann A, Ludwig B.
Horm Metab Res. 2023 Nov 13. doi: 10.1055/a-2190-2803. Online ahead of print. PMID: 37956864
FSP1 inhibition: pick your pocket.

Bebber CM, von Karstedt S.
Nat Struct Mol Biol. 2023 Nov;30(11):1618-1619. doi: 10.1038/s41594-023-01145-x. PMID: 37957304 No abstract available.
Metformin potentiates nephrotoxicity by promoting NETosis in response to renal ferroptosis.

Cai Z, Wu X, Song Z, Sun S, Su Y, Wang T, Cheng X, Yu Y, Yu C, Chen E, Chen W, Yu Y, Linkermann A, Min J, Wang F.

Cell Discov. 2023 Oct 17;9(1):104. doi: 10.1038/s41421-023-00595-3. PMID: 37848438 Free PMC article.
Ferroptosis contributes to multiple sclerosis and its pharmacological targeting suppresses experimental disease progression.

Van San E, Debruyne AC, Veeckmans G, Tyurina YY, Tyurin VA, Zheng H, Choi SM, Augustyns K, van Loo G, Michalke B, Venkataramani V, Toyokuni S, Bayir H, Vandenabeele P, Hassannia B, Vanden Berghe T.

Cell Death Differ. 2023 Sep;30(9):2092-2103. doi: 10.1038/s41418-023-01195-0. Epub 2023 Aug 4. PMID: 37542104 Free PMC article.
Ferroptosis induces detrimental effects in chronic EAE and its implications for progressive MS.

Jhelum P, Zandee S, Ryan F, Zarruk JG, Michalke B, Venkataramani V, Curran L, Klement W, Prat A, David S.

Acta Neuropathol Commun. 2023 Jul 25;11(1):121. doi: 10.1186/s40478-023-01617-7. PMID: 37491291 Free PMC article.
Investigating the Potential of Drift Tube Ion Mobility for the Analysis of Oxidized Lipids.

da Silva KM, Wölk M, Nepachalovich P, Iturrospe E, Covaci A, van Nuijs ALN, Fedorova M.

Anal Chem. 2023 Sep 12;95(36):13566-13574. doi: 10.1021/acs.analchem.3c02213. Epub 2023 Aug 30. PMID: 37646365
Mutual regulation of TGFβ-induced oncogenic EMT, cell cycle progression and the DDR.

Schuhwerk H, Brabletz T.

Semin Cancer Biol. 2023 Dec;97:86-103. doi: 10.1016/j.semcancer.2023.11.009. Epub 2023 Nov 28. PMID: 38029866 Free article. Review.
Integrated chemical and genetic screens unveil FSP1 mechanisms of ferroptosis regulation.

Nakamura T, Mishima E, Yamada N, Mourão ASD, Trümbach D, Doll S, Wanninger J, Lytton E, Sennhenn P, Nishida Xavier da Silva T, Angeli JPF, Sattler M, Proneth B, Conrad M.

Nat Struct Mol Biol. 2023 Nov;30(11):1806-1815. doi: 10.1038/s41594-023-01136-y. Epub 2023 Nov 13. PMID: 37957306 Free PMC article.
Mechanisms controlling cellular and systemic iron homeostasis.

Galy B, Conrad M, Muckenthaler MU
Nat Rev Mol Cell Biol. 2023 Oct 2. doi: 10.1038/s41580-023-00648-1. Online ahead of print. PMID: 37783783 Review.
p53 deficient breast cancer cells reprogram preadipocytes toward tumor-protective immunomodulatory cells.

Hassin O, Sernik M, Seligman A, Vogel FCE, Wellenstein MD, Smollich J, Halperin C, Pirona AC, Toledano LN, Caballero CD, Schlicker L, Salame TM, Sarusi Portuguez A, Aylon Y, Scherz-Shouval R, Geiger T, de Visser KE, Schulze A, Oren M.
Proc Natl Acad Sci U S A. 2023 Dec 26;120(52):e2311460120. doi: 10.1073/pnas.2311460120. Epub 2023 Dec 21.PMID: 38127986 Free PMC article.

Emergence of (hydro)persulfides as suppressors of lipid peroxidation and ferroptotic cell death.

Wu Z, Barayeu U, Schilling D, Dick TP, Pratt DA.

Curr Opin Chem Biol. 2023 Oct;76:102353. doi: 10.1016/j.cbpa.2023.102353. Epub 2023 Jun 24. PMID: 37356334 Review.
Calcium as a master regulator of ferroptosis and other types of regulated necrosis.

Pedrera L, Ros U, García-Sáez AJ.

Cell Calcium. 2023 Sep;114:102778. doi: 10.1016/j.ceca.2023.102778. Epub 2023 Jun 19. PMID: 37356350 Review.
Methane formation driven by light and heat prior to the origin of life and beyond.

Ernst L, Barayeu U, Hädeler J, Dick TP, Klatt JM, Keppler F, Rebelein JG.
Nat Commun. 2023 Aug 1;14(1):4364. doi: 10.1038/s41467-023-39917-0. PMID: 37528079 Free PMC article.
Endocrine communication of endoplasmic reticulum stress.

Gómez AM, Bartelt A.

Bioessays. 2023 Aug;45(8):e2300093. doi: 10.1002/bies.202300093. Epub 2023 Jun 15. PMID: 37318317 No abstract available.
LRP8-mediated selenocysteine uptake is a targetable vulnerability in MYCN-amplified neuroblastoma.

Alborzinia H, Chen Z, Yildiz U, Freitas FP, Vogel FCE, Varga JP, Batani J, Bartenhagen C, Schmitz W, Büchel G, Michalke B, Zheng J, Meierjohann S, Girardi E, Espinet E, Flórez AF, Dos Santos AF, Aroua N, Cheytan T, Haenlin J, Schlicker L, Xavier da Silva TN, Przybylla A, Zeisberger P, Superti-Furga G, Eilers M, Conrad M, Fabiano M, Schweizer U, Fischer M, Schulze A, Trumpp A, Friedmann Angeli JP.

EMBO Mol Med. 2023 Jul 12:e18014. doi: 10.15252/emmm.202318014. Online ahead of print. PMID: 37435859 Free article.
A distinct stimulatory cDC1 subpopulation amplifies CD8+ T cell responses in tumors for protective anti-cancer immunity.

Meiser P, Knolle MA, Hirschberger A, de Almeida GP, Bayerl F, Lacher S, Pedde AM, Flommersfeld S, Hönninger J, Stark L, Stögbauer F, Anton M, Wirth M, Wohlleber D, Steiger K, Buchholz VR, Wollenberg B, Zielinski CE, Braren R, Rueckert D, Knolle PA, Kaissis G, Böttcher JP.

Cancer Cell. 2023 Jul 11:S1535-6108(23)00218-0. doi: 10.1016/j.ccell.2023.06.008. Online ahead of print. PMID: 37451271 Free article.
Phase separation of FSP1 promotes ferroptosis.

Nakamura T, Hipp C, Santos Dias Mourão A, Borggräfe J, Aldrovandi M, Henkelmann B, Wanninger J, Mishima E, Lytton E, Emler D, Proneth B, Sattler M, Conrad M.

Nature. 2023 Jul;619(7969):371-377. doi: 10.1038/s41586-023-06255-6. Epub 2023 Jun 28.PMID: 37380771
Cholesterol atlas of tumor microenvironment provides route to improved CAR-T therapy.

Chaves-Filho AB, Schulze A.

Cancer Cell. 2023 Jul 10;41(7):1204-1206. doi: 10.1016/j.ccell.2023.05.013. Epub 2023 May 26. PMID: 37244258
The influence of alkylating agents on sulfur-sulfur bonds in per- and polysulfides.

Schilling D, Ditrói T, Barayeu U, Jurányi EP, Nagy P, Dick TP.

Curr Opin Chem Biol. 2023 Jul 18;76:102368. doi: 10.1016/j.cbpa.2023.102368. Online ahead of print. PMID: 37473483 Review.
DHODH inhibitors sensitize to ferroptosis by FSP1 inhibition.

Mishima E, Nakamura T, Zheng J, Zhang W, Mourão ASD, Sennhenn P, Conrad M.

Nature. 2023 Jul;619(7968):E9-E18. doi: 10.1038/s41586-023-06269-0. Epub 2023 Jul 5.PMID: 37407687
Hepatic inflammatory responses in liver fibrosis.

Hammerich L, Tacke F.

Nat Rev Gastroenterol Hepatol. 2023 Jul 3. doi: 10.1038/s41575-023-00807-x. Online ahead of print. PMID: 37400694 Review.
Low level of antioxidant capacity biomarkers but not target overexpression predicts vulnerability to ROS-inducing drugs.

Samarin J, Fabrowski P, Kurilov R, Nuskova H, Hummel-Eisenbeiss J, Pink H, Li N, Weru V, Alborzinia H, Yildiz U, Grob L, Taubert M, Czech M, Morgen M, Brandstädter C, Becker K, Mao L, Jayavelu AK, Goncalves A, Uhrig U, Seiler J, Lyu Y, Diederichs S, Klingmüller U, Muckenthaler M, Kopp-Schneider A, Teleman A, Miller AK, Gunkel N.

Redox Biol. 2023 Jun;62:102639. doi: 10.1016/j.redox.2023.102639. Epub 2023 Feb 23. PMID: 36958250 Free PMC article.
Tumor-derived prostaglandin E2 programs cDC1 dysfunction to impair intratumoral orchestration of anti-cancer T cell responses.

Bayerl F, Meiser P, Donakonda S, Hirschberger A, Lacher SB, Pedde AM, Hermann CD, Elewaut A, Knolle M, Ramsauer L, Rudolph TJ, Grassmann S, Öllinger R, Kirchhammer N, Trefny M, Anton M, Wohlleber D, Höchst B, Zaremba A, Krüger A, Rad R, Obenauf AC, Schadendorf D, Zippelius A, Buchholz VR, Schraml BU, Böttcher JP.

Immunity. 2023 Jun 13;56(6):1341-1358.e11. doi: 10.1016/j.immuni.2023.05.011. PMID: 37315536 Free article.
Diverse biological functions of vitamin K: from coagulation to ferroptosis.

Mishima E, Wahida A, Seibt T, Conrad M.

Nat Metab. 2023 Jun;5(6):924-932. doi: 10.1038/s42255-023-00821-y. Epub 2023 Jun 19. PMID: 37337123 Review.
Sublethal necroptosis signaling promotes inflammation and liver cancer.

Vucur M, Ghallab A, Schneider AT, Adili A, Cheng M, Castoldi M, Singer MT, Büttner V, Keysberg LS, Küsgens L, Kohlhepp M, Görg B, Gallage S, Barragan Avila JE, Unger K, Kordes C, Leblond AL, Albrecht W, Loosen SH, Lohr C, Jördens MS, Babler A, Hayat S, Schumacher D, Koenen MT, Govaere O, Boekschoten MV, Jörs S, Villacorta-Martin C, Mazzaferro V, Llovet JM, Weiskirchen R, Kather JN, Starlinger P, Trauner M, Luedde M, Heij LR, Neumann UP, Keitel V, Bode JG, Schneider RK, Tacke F, Levkau B, Lammers T, Fluegen G, Alexandrov T, Collins AL, Nelson G, Oakley F, Mann DA, Roderburg C, Longerich T, Weber A, Villanueva A, Samson AL, Murphy JM, Kramann R, Geisler F, Costa IG, Hengstler JG, Heikenwalder M, Luedde T.

Immunity. 2023 Jun 12:S1074-7613(23)00234-0. doi: 10.1016/j.immuni.2023.05.017. Online ahead of print. PMID: 37329888 Free article.
Ferroptosis: mechanisms and implications for cancer development and therapy response.

Dos Santos AF, Fazeli G, Xavier da Silva TN, Friedmann Angeli JP.

Trends Cell Biol. 2023 May 23:S0962-8924(23)00079-X. doi: 10.1016/j.tcb.2023.04.005. Online ahead of print. PMID: 37230924 Review.
vPIF-1 is an insulin-like antiferroptotic viral peptide.

Belavgeni A, Maremonti F, Tonnus W, Stadtmüller M, Gavali S, Mallais M, Flade K, Brucker A, Becker JN, Beer K, Tmava M, Stumpf J, Gembardt F, Hugo C, Giacca M, Hale BG, Perakakis N, Sha W, Pratt DA, Schally AV, Bornstein SR, Linkermann A.

Proc Natl Acad Sci U S A. 2023 May 23;120(21):e2300320120. doi: 10.1073/pnas.2300320120. Epub 2023 May 15. PMID: 37186845 Free PMC article.
Consensus Statement on the definition and classification of metabolic hyperferritinaemia.

Valenti L, Corradini E, Adams LA, Aigner E, Alqahtani S, Arrese M, Bardou-Jacquet E, Bugianesi E, Fernandez-Real JM, Girelli D, Hagström H, Henninger B, Kowdley K, Ligabue G, McClain D, Lainé F, Miyanishi K, Muckenthaler MU, Pagani A, Pedrotti P, Pietrangelo A, Prati D, Ryan JD, Silvestri L, Spearman CW, Stål P, Tsochatzis EA, Vinchi F, Zheng MH, Zoller H.

Nat Rev Endocrinol. 2023 May;19(5):299-310. doi: 10.1038/s41574-023-00807-6. Epub 2023 Feb 17. PMID: 36805052 Free PMC article. Review.
Resolving 31 colors on a standard 3-laser full spectrum flow cytometer for immune monitoring of human blood samples.

Hammerich L, Shevchenko Y, Knorr J, Werner W, Bruneau A, Tacke F.

Cytometry B Clin Cytom. 2023 May 20. doi: 10.1002/cyto.b.22126. Online ahead of print. PMID: 37209003
The role of proteasome activators PA28αβ and PA200 in brown adipocyte differentiation and function.

Koçberber Z, Willemsen N, Bartelt A.
Front Endocrinol (Lausanne). 2023 May 2;14:1176733. doi: 10.3389/fendo.2023.1176733. eCollection 2023. PMID: 37201100 Free PMC article.
3-Mercaptopyruvate sulfur transferase is a protein persulfidase.

Pedre B, Talwar D, Barayeu U, Schilling D, Luzarowski M, Sokolowski M, Glatt S, Dick TP.

Nat Chem Biol. 2023 Apr;19(4):507-517. doi: 10.1038/s41589-022-01244-8. Epub 2023 Feb 2. PMID: 36732619 Free PMC article.
Molecular characterization of AIFM2/FSP1 inhibition by iFSP1-like molecules.

Xavier da Silva TN, Schulte C, Alves AN, Maric HM, Friedmann Angeli JP.

Cell Death Dis. 2023 Apr 21;14(4):281. doi: 10.1038/s41419-023-05787-z. PMID: 37080964 Free PMC article.
Triglyceride cycling enables modification of stored fatty acids.

Wunderling K, Zurkovic J, Zink F, Kuerschner L, Thiele C.

Nat Metab. 2023 Apr;5(4):699-709. doi: 10.1038/s42255-023-00769-z. Epub 2023 Apr 3. PMID: 37012495 Free PMC article.
Analytical Toolbox to Unlock the Diversity of Oxidized Lipids.

Wölk M, Prabutzki P, Fedorova M.

Acc Chem Res. 2023 Apr 4;56(7):835-845. doi: 10.1021/acs.accounts.2c00842. Epub 2023 Mar 21. PMID: 36943749
Editorial to the Special Issue "Homeostasis: Metals and Cellular Redox and Immunity Status".

Michalke B, Venkataramani V.

Int J Mol Sci. 2023 Mar 3;24(5):4889. doi: 10.3390/ijms24054889. PMID: 36902319 Free PMC article.
Immunological consequences of arsenic trioxide-induced necrosis.

Gavali S, Tonnus W, Linkermann A.
Cell Mol Immunol. 2023 Mar;20(3):308-309. doi: 10.1038/s41423-023-00976-4. Epub 2023 Jan 25. PMID: 36693921 Free PMC article. No abstract available.
Hepatic Stellate Cells: Dictating Outcome in Nonalcoholic Fatty Liver Disease.

Wiering L, Subramanian P, Hammerich L.

Cell Mol Gastroenterol Hepatol. 2023;15(6):1277-1292. doi: 10.1016/j.jcmgh.2023.02.010. Epub 2023 Feb 23. PMID: 36828280 Free PMC article. Review.
Guiding the choice of informatics software and tools for lipidomics research applications.

Ni Z, Wölk M, Jukes G, Mendivelso Espinosa K, Ahrends R, Aimo L, Alvarez-Jarreta J, Andrews S, Andrews R, Bridge A, Clair GC, Conroy MJ, Fahy E, Gaud C, Goracci L, Hartler J, Hoffmann N, Kopczyinki D, Korf A, Lopez-Clavijo AF, Malik A, Ackerman JM, Molenaar MR, O’Donovan C, Pluskal T, Shevchenko A, Slenter D, Siuzdak G, Kutmon M, Tsugawa H, Willighagen EL, Xia J, O’Donnell VB, Fedorova M.

Nat Methods. 2023 Feb;20(2):193-204. doi: 10.1038/s41592-022-01710-0. Epub 2022 Dec 21. PMID: 36543939 Free PMC article. Review.
Guidelines for visualization and analysis of DC in tissues using multiparameter fluorescence microscopy imaging methods.

Bayerl F, Bejarano DA, Bertacchi G, Doffin AC, Gobbini E, Hubert M, Li L, Meiser P, Pedde AM, Posch W, Rupp L, Schlitzer A, Schmitz M, Schraml BU, Uderhardt S, Valladeau-Guilemond J, Wilflingseder D, Zaderer V, Böttcher JP.

Eur J Immunol. 2023 Jan 9:e2249923. doi: 10.1002/eji.202249923. Online ahead of print. PMID: 36623939
Hydropersulfides inhibit lipid peroxidation and ferroptosis by scavenging radicals.

Barayeu U, Schilling D, Eid M, Xavier da Silva TN, Schlicker L, Mitreska N, Zapp C, Gräter F, Miller AK, Kappl R, Schulze A, Friedmann Angeli JP, Dick TP.

Nat Chem Biol. 2023 Jan;19(1):28-37. doi: 10.1038/s41589-022-01145-w. Epub 2022 Sep 15. PMID: 36109647 Free PMC article.
Mitochondrial ferritin expression in human macrophages is facilitated by thrombin-mediated cleavage under hypoxia.

Fuhrmann DC, Becker S, Brüne B.

FEBS Lett. 2023 Jan;597(2):276-287. doi: 10.1002/1873-3468.14545. Epub 2022 Dec 1. PMID: 36416578

2022

Analytical and computational workflow for in-depth analysis of oxidized complex lipids in blood plasma.

Criscuolo A, Nepachalovich P, Garcia-Del Rio DF, Lange M, Ni Z, Baroni M, Cruciani G, Goracci L, Blüher M, Fedorova M.

Nat Commun. 2022 Nov 1;13(1):6547. doi: 10.1038/s41467-022-33225-9. PMID: 36319635 Free PMC article.
Mitochondrial ferritin expression in human macrophages is facilitated by thrombin-mediated cleavage under hypoxia.

Fuhrmann DC, Becker S, Brüne B.

FEBS Lett. 2022 Nov 23. doi: 10.1002/1873-3468.14545. Online ahead of print.PMID: 36416578
TREM-2 plays a protective role in cholestasis by acting as a negative regulator of inflammation.

Labiano I, Agirre-Lizaso A, Olaizola P, Echebarria A, Huici-Izagirre M, Olaizola I, Esparza-Baquer A, Sharif O, Hijona E, Milkiewicz P, Milkiewicz M, González-Romero F, Aspichueta P, Monte MJ, Marin JJG, Vucur M, Luedde T, Marzioni M, Mann DA, Bujanda L, Rodrigues PM, Banales JM, Perugorria MJ.

J Hepatol. 2022 Oct;77(4):991-1004. doi: 10.1016/j.jhep.2022.05.044. Epub 2022 Jun 22. PMID: 35750136 Free article.
A crosstalk between hepcidin and IRE/IRP pathways controls ferroportin expression and determines serum iron levels in mice.

Charlebois E, Fillebeen C, Katsarou A, Rabinovich A, Wisniewski K, Venkataramani V, Michalke B, Velentza A, Pantopoulos K.

Elife. 2022 Sep 6;11:e81332. doi: 10.7554/eLife.81332. PMID: 36066082 Free PMC article.
Gasdermin D-deficient mice are hypersensitive to acute kidney injury.

Tonnus W, Maremonti F, Belavgeni A, Latk M, Kusunoki Y, Brucker A, von Mässenhausen A, Meyer C, Locke S, Gembardt F, Beer K, Hoppenz P, Becker JU, Hugo C, Anders HJ, Bornstein SR, Shao F, Linkermann A.

Cell Death Dis. 2022 Sep 15;13(9):792. doi: 10.1038/s41419-022-05230-9.PMID: 36109515 Free PMC article.
Erythropoietin-driven dynamic proteome adaptations during erythropoiesis prevent iron overload in the developing embryo.

Chakraborty S, Andrieux G, Kastl P, Adlung L, Altamura S, Boehm ME, Schwarzmüller LE, Abdullah Y, Wagner MC, Helm B, Gröne HJ, Lehmann WD, Boerries M, Busch H, Muckenthaler MU, Schilling M, Klingmüller U.

Cell Rep. 2022 Sep 20;40(12):111360. doi: 10.1016/j.celrep.2022.111360. PMID: 36130519 Free article.
Golgi Protein 73 (GP73) Serum Levels Predict Outcome after Resection of Biliary Tract Cancer.

Loosen SH, Halpaap J, Labuhn S, Bednarsch J, Alizai PH, Roeth AA, Lang SA, Vucur M, Kather JN, Knoefel WT, Ulmer TF, Neumann UP, Roderburg C, Luedde T.

Cancers (Basel). 2022 Sep 12;14(18):4428. doi: 10.3390/cancers14184428. PMID: 36139589 Free PMC article.
Nutritional and Metabolic Control of Ferroptosis.

Mishima E, Conrad M.

Annu Rev Nutr. 2022 Aug 22;42:275-309. doi: 10.1146/annurev-nutr-062320-114541. Epub 2022 Jun 1.PMID: 35650671 Review.
Serum Levels of CXCL13 Are an Independent Predictor of Survival Following Resection of Biliary Tract Cancer.

Loosen SH, Ulmer TF, Labuhn S, Bednarsch J, Lang SA, Alizai PH, Schneider AT, Vucur M, Neumann UP, Luedde T, Roderburg C.

Cancers (Basel). 2022 Aug 23;14(17):4073. doi: 10.3390/cancers14174073. PMID: 36077611 Free PMC article.
A non-canonical vitamin K cycle is a potent ferroptosis suppressor.

Mishima E, Ito J, Wu Z, Nakamura T, Wahida A, Doll S, Tonnus W, Nepachalovich P, Eggenhofer E, Aldrovandi M, Henkelmann B, Yamada KI, Wanninger J, ZilkaO, Sato E, Feederle R, Hass D, Maida A, Mourão ASD, Linkermann A, Geissler EK, Nakagawa K, Abe T, Fedorova M, Proneth B, Pratt DA, Conrad M.

Nature. 2022 Aug;608(7924):778-783. doi: 10.1038/s41586-022-05022-3. Epub 2022 Aug 3.PMID: 35922516
Intrinsic and Extrinsic Limitations to the Design and Optimization of Inhibitors of Lipid Peroxidation and Associated Cell Death.

Farmer LA, Wu Z, Poon JF, Zilka O, Lorenz SM, Huehn S, Proneth B, Conrad M, Pratt DA.

J Am Chem Soc. 2022 Aug 17;144(32):14706-14721. doi: 10.1021/jacs.2c05252. Epub 2022 Aug 3.PMID: 35921655
A graphical journey through iron metabolism, microRNAs, and hypoxia in ferroptosis.

Fuhrmann DC, Brüne B.

Redox Biol. 2022 Aug;54:102365. doi: 10.1016/j.redox.2022.102365. Epub 2022 Jun 9. PMID: 35717888 Free PMC article. Review.
Commonly Used Alkylating Agents Limit Persulfide Detection by Converting Protein Persulfides into Thioethers.

Schilling D, Barayeu U, Steimbach RR, Talwar D, Miller AK, Dick TP.

Angew Chem Int Ed Engl. 2022 Jul 25;61(30):e202203684. doi: 10.1002/anie.202203684. Epub 2022 May 24.PMID: 35506673
Interplay of Nrf2 and BACH1 in inducing ferroportin expression and enhancing resistance of human macrophages towards ferroptosis.

Namgaladze D, Fuhrmann DC, Brüne B.

Cell Death Discov. 2022 Jul 19;8(1):327. doi: 10.1038/s41420-022-01117-y. PMID: 35853860 Free PMC article.
Apolipoprotein E potently inhibits ferroptosis by blocking ferritinophagy.

Belaidi AA, Masaldan S, Southon A, Kalinowski P, Acevedo K, Appukuttan AT, Portbury S, Lei P, Agarwal P, Leurgans SE, Schneider J, Conrad M, Bush AI, Ayton S.

Mol Psychiatry. 2022 Apr 28:10.1038/s41380-022-01568-w. doi: 10.1038/s41380-022-01568-w. Online ahead of print. PMID: 35484240
Glioblastoma Relapses Show Increased Markers of Vulnerability to Ferroptosis.

Kram H, Prokop G, Haller B, Gempt J, Wu Y, Schmidt-Graf F, Schlegel J, Conrad M, Liesche-Starnecker F.

Front Oncol. 2022 Apr 21;12:841418. doi: 10.3389/fonc.2022.841418. eCollection 2022.PMID: 35530303
MYCN mediates cysteine addiction and sensitizes neuroblastoma to ferroptosis.

Alborzinia H, Flórez AF, Kreth S, Brückner LM, Yildiz U, Gartlgruber M, Odoni DI, Poschet G, Garbowicz K, Shao C, Klein C, Meier J, Zeisberger P, Nadler-Holly M, Ziehm M, Paul F, Burhenne J, Bell E, Shaikhkarami M, Würth R, Stainczyk SA, Wecht EM, Kreth J, Büttner M, Ishaque N, Schlesner M, Nicke B, Stresemann C, Llamazares-Prada M, Reiling JH, Fischer M, Amit I, Selbach M, Herrmann C, Wölfl S, Henrich KO, Höfer T, Trumpp A, Westermann F.

Nat Cancer. 2022 Apr;3(4):471-485. doi: 10.1038/s43018-022-00355-4. Epub 2022 Apr 28. PMID: 35484422 Free PMC article.
The arginine methyltransferase PRMT7 promotes extravasation of monocytes resulting in tissue injury in COPD.

Günes Günsel G, Conlon TM, Jeridi A, Kim R, Ertüz Z, Lang NJ, Ansari M, Novikova M, Jiang D, Strunz M, Gaianova M, Hollauer C, Gabriel C, Angelidis I, Doll S, Pestoni JC, Edelmann SL, Kohlhepp MS, Guillot A, Bassler K, Van Eeckhoutte HP, Kayalar Ö, Konyalilar N, Kanashova T, Rodius S, Ballester-López C, Genes Robles CM, Smirnova N, Rehberg M, Agarwal C, Krikki I, Piavaux B, Verleden SE, Vanaudenaerde B, Königshoff M, Dittmar G, Bracke KR, Schultze JL, Watz H, Eickelberg O, Stoeger T, Burgstaller G, Tacke F, Heissmeyer V, Rinkevich Y, Bayram H, Schiller HB, Conrad M, Schneider R, Yildirim AÖ.

Nat Commun. 2022 Mar 14;13(1):1303. doi: 10.1038/s41467-022-28809-4.PMID: 35288557
NFE2L1-mediated proteasome function protects from ferroptosis.

Kotschi S, Jung A, Willemsen N, Ofoghi A, Proneth B, Conrad M, Bartelt A.

Mol Metab. 2022 Mar;57:101436. doi: 10.1016/j.molmet.2022.101436. Epub 2022 Jan 6.PMID: 34999280
Ferroptosis in Cancer Immunotherapy—Implications for Hepatocellular Carcinoma.

Kusnick, J, Bruneau, A, Tacke, F, Hammerich, L.

Immuno, 2(1) 2022, 185-217. doi.org/10.3390/immuno2010014
Direct neuronal reprogramming: Fast forward from new concepts toward therapeutic approaches.

Bocchi R, Masserdotti G, Götz M.

Neuron. 2022 Feb 2;110(3):366-393. doi: 10.1016/j.neuron.2021.11.023. Epub 2021 Dec 18. PMID: 34921778 Free article. Review.
Persister cancer cells: Iron addiction and vulnerability to ferroptosis.

Rodriguez R, Schreiber SL, Conrad M.

Mol Cell. 2022 Feb 17;82(4):728-740. doi: 10.1016/j.molcel.2021.12.001. Epub 2021 Dec 28.PMID: 34965379 Review.
Epithelial-mesenchymal transition and H2O2 signaling - a driver of disease progression and a vulnerability in cancers

Milton AV, Konrad DB.

Biol Chem. 2022 Jan 17;403(4):377-390. doi: 10.1515/hsz-2021-0341. Print 2022 Mar 28. PMID: 35032422 Review.

2021

Missense mutation in selenocysteine synthase causes cardio-respiratory failure and perinatal death in mice which can be compensated by selenium-independent GPX4.

Fradejas-Villar N, Zhao W, Reuter U, Doengi M, Ingold I, Bohleber S, Conrad M, Schweizer U.

Redox Biol. 2021 Nov 12;48:102188. doi: 10.1016/j.redox.2021.102188. Online ahead of print.PMID: 34794077
Embryonal erythropoiesis and aging exploit ferroptosis.

Zheng H, Jiang L, Tsuduki T, Conrad M, Toyokuni S.

Redox Biol. 2021 Oct 30;48:102175. doi: 10.1016/j.redox.2021.102175. Online ahead of print.PMID: 34736120
Fin56-induced ferroptosis is supported by autophagy-mediated GPX4 degradation and functions synergistically with mTOR inhibition to kill bladder cancer cells.

Sun Y, Berleth N, Wu W, Schlütermann D, Deitersen J, Stuhldreier F, Berning L, Friedrich A, Akgün S, Mendiburo MJ, Wesselborg S, Conrad M, Berndt C, Stork B.

Cell Death Dis. 2021 Oct 29;12(11):1028. doi: 10.1038/s41419-021-04306-2.PMID: 34716292
Dysfunction of the key ferroptosis-surveilling systems hypersensitizes mice to tubular necrosis during acute kidney injury.

Tonnus W, Meyer C, Steinebach C, Belavgeni A, von Mässenhausen A, Gonzalez NZ, Maremonti F, Gembardt F, Himmerkus N, Latk M, Locke S, Marschner J, Li W, Short S, Doll S, Ingold I, Proneth B, Daniel C, Kabgani N, Kramann R, Motika S, Hergenrother PJ, Bornstein SR, Hugo C, Becker JU, Amann K, Anders HJ, KreiselD, Pratt D, Gütschow M, Conrad M, Linkermann A.

Nat Commun. 2021 Jul 20;12(1):4402. doi: 10.1038/s41467-021-24712-6.PMID: 34285231
Sorafenib fails to trigger ferroptosis across a wide range of cancer cell lines.

Zheng J, Sato M, Mishima E, Sato H, Proneth B, Conrad M.

Cell Death Dis. 2021 Jul 13;12(7):698. doi: 10.1038/s41419-021-03998-w.PMID: 34257282
Non-enzymatic lipid peroxidation initiated by photodynamic therapy drives a distinct ferroptosis-like cell death pathway.

Shui S, Zhao Z, Wang H, Conrad M, Liu G.

Redox Biol. 2021 Sep;45:102056. doi: 10.1016/j.redox.2021.102056. Epub 2021 Jun 23.PMID: 34229160
BNIP3 promotes HIF-1α-driven melanoma growth by curbing intracellular iron homeostasis

Vara-Pérez M, Rossi M, Van den Haute C, Maes H, Sassano ML, Venkataramani V, Michalke B, Romano E, Rillaerts K, Garg AD, Schepkens C, Bosisio FM, Wouters J, Oliveira AI, Vangheluwe P, Annaert W, Swinnen JV, Colet JM, van den Oord JJ, Fendt SM, Mazzone M, Agostinis P.

EMBO J. 2021 May 17;40(10):e106214. doi: 10.15252/embj.2020106214. Epub 2021 May 1. PMID: 33932034 Free PMC article.
Simultaneous Quantification and Speciation of Trace Metals in Paired Serum and CSF Samples by Size Exclusion Chromatography-Inductively Coupled Plasma-Dynamic Reaction Cell-Mass Spectrometry (SEC-DRC-ICP-MS).

Michalke B, Berthele A, Venkataramani V.

Int J Mol Sci. 2021 Aug 18;22(16):8892. doi: 10.3390/ijms22168892. PMID: 34445607 Free PMC article.
Fatty acid synthesis enables brain metastasis

Vogel FCE, Schulze A.

Nat Cancer. 2021 Apr;2(4):374-376. doi: 10.1038/s43018-021-00202-y. PMID: 35122002 No abstract available.
Iron Homeostasis and Metabolism: Two Sides of a Coin

Venkataramani V.

Adv Exp Med Biol. 2021;1301:25-40. doi: 10.1007/978-3-030-62026-4_3. PMID: 34370286 Review.

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