2026
- Metabolic plasticity and optimal redox homeostasis are essential for efficient metastatic colonization.Mol Metab. 2026 Jul;109:102382. doi: 10.1016/j.molmet.2026.102382.
- Cytosolic PRDX1 acts as an extramitochondrial sink to set mitochondrial H2O2 levels and enable resilience to chronic mitochondrial oxidative stress.
Redox Biol. 2026 Jul;94:104195. doi: 10.1016/j.redox.2026.104195. Epub 2026 Apr 30. PMID: 42085864 Free PMC article.
- Oncogenic KRAS-driven type I interferon signalling primes pancreatic cancer for necroptosis.
Tishina S, Dahlhaus A, Manik M, Mulalic L, Murr J, Kotliar M, Rakhsh-Khorshid H, Kostopoulou M, Hocher F, Stroh J, Beck J, Williams RM, Balta GG, Liu F, Abdallah AT, Bebber CM, Reese M, Lim JKM, Quaas A, Brägelmann J, Pasparakis M, Beleggia F, Balachandran S, Trauzold A, Liccardi G, Astsaturov I, Reichert M, Androulidaki A, von Karstedt S.
Nat Commun. 2026 Jun 15;17(1):5288. doi: 10.1038/s41467-026-73189-8.PMID: 42297776
- Ferroptosis inhibition enhances liver and lung graft function.Veeckmans G, Devos L, Gilbo N, Van Beersel D, Scarpellini C, Blondeel J, Walravens M, Klejborowska G, Lanthier C, Wölk M, Müller S, Gaillet C, Colombeau L, Hassannia B, Längin M, Bender M, Abicht JM, Reichart B, De Winter H, Fedorova M, Rodriguez R, Pirenne J, Ceulemans LJ, Jochmans I, Augustyns K, Monbaliu D, Neyrinck A, Vanden Berghe T.
Cell. 2026 Jun 25;189(13):3991-4004.e26. doi: 10.1016/j.cell.2026.04.024. Epub 2026 May 8.PMID: 42105762
- Tipping the balance: NRF2’s dual role in ferroptotic fate.Oncogenesis. 2026 May 30;15(1):26. doi: 10.1038/s41389-026-00630-4.PMID: 42218132 Review.
- A ZEB1-Neon knock-in uncovers traceable dynamics of epithelial-mesenchymal transition in tumors in vivo.
BMC Biol. 2026 May 12;24(1):116. doi: 10.1186/s12915-026-02629-0.PMID: 42121129
- A lipidomics roadmap: from basic research to societal challenges.
Fedorova M, Bendt AK, Bertrand-Michel J, Fiehn O, Godzien J, Goracci L, Gruber F, Guan XL, Han X, Holčapek M, Kuligowski J, Meikle PJ, Nepachalovich P, O’Donnell VB, Orešič M, Penkov S, Petrović S, Potapov A, Prabutzki P, Righetti L, Ruskovska T, Shevchenko A, Simons K, Spickett CM, Vvedenskaya O, Watts J, Wenk MR, Witting M, Xia Y, Yang B, Domingues MR.
Nat Commun. 2026 May 28;17(1):4778. doi: 10.1038/s41467-026-73797-4.PMID: 42209482
- Multiomics immune profiling of a patient-relevant orthotopic lung cancer model using SEPARATE-Seq.
Bardet PMR, Allonsius L, Hadadi E, Kancheva D, Paque M, Vosahlikova S, Caro AA, Van Audenhove A, Debraekeleer A, Roelandt R, Verstaen K, Hensler M, Hoton D, Mateu Cabrera G, Boon L, Blomme A, Deschoemaeker S, Raes G, Marcq E, Hamouda AEI, Böttcher JP, Fucikova J, Close P, Aboubakar Nana F, Laoui D.
Nat Commun. 2026 Apr 23;17(1):5611. doi: 10.1038/s41467-026-72247-5. PMID: 42026061
- Ferritin and transferrin predict common carotid intima-media thickness in females: a machine-learning informed individual participant data meta-analysis.
Ruban Agarvas A, Sparla R, Atkins JL, Altamura C, Anderson T, Asicioglu E, Bassols J, López-Bermejo A, Dvořáková HM, Fernández-Real JM, Hochmayr C, Knoflach M, Milicevic JK, Lai S, Moreno-Navarrete JM, Pawlak D, Pawlak K, Syrovatka P, Formanowicz D, Kraml P, Valdivielso JM, Valenti L, Muckenthaler MU.
BMC Cardiovasc Disord. 2026 Apr 14;26(1):360. doi: 10.1186/s12872-026-05796-8.PMID: 41981480
- Ablation of prostaglandin E2 signalling through dual receptor knockout in CAR T cells enhances therapeutic efficacy in solid tumours.Nat Biomed Eng. 2026 Apr;10(4):697-710. doi: 10.1038/s41551-025-01610-6. Epub 2026 Feb 11.PMID: 41673138
- Regulated necrosis at the crossroads of liver inflammation and cancer development.
Vucur M, Kondylis V, Broz P, Luedde T.
Nat Rev Gastroenterol Hepatol. 2026 Apr;23(4):331-354. doi: 10.1038/s41575-025-01147-8. Epub 2025 Nov 24. PMID: 41286030 Review.
- Cell death in cancer.Cell. 2026 Apr 16;189(8):2322-2356. doi: 10.1016/j.cell.2026.03.024. PMID: 41997127 Free article. Review.
- Differential KEAP1/NRF2 mediated signaling widens the therapeutic window of redox-targeting drugs in SCLC therapy.
Samarin J, Nůsková H, Fabrowski P, Malz M, Amtmann E, Taeubert MJ, Pastor-Flores D, Kazdal D, Kurilov R, de Vries N, Pink H, Deis F, Hummel-Eisenbeiss J, Renz L, Kaushal K, Morgen M, Dick TP, Hamilton G, Muckenthaler M, Mall M, Lim B, Kanamaru T, Klinke G, Sos ML, Frede J, Miller AK, Alborzinia H, Gunkel N.
Nat Commun. 2026 Apr 12;17(1):3435. doi: 10.1038/s41467-026-71608-4.PMID: 41965332
- A feedback loop between cell proliferation and ROS regulates ferroptosis sensitivity.
Seidel E, Itak EY, Müller F, Yapici FI, Brägelmann J, Berg J, von Karstedt S.
Front Cell Dev Biol. 2026 Mar 25;14:1756238. doi: 10.3389/fcell.2026.1756238. eCollection 2026.PMID: 41960191
- Riboflavin metabolism shapes FSP1-driven ferroptosis resistance.
Skafar V, de Souza I, Ghosh B, Ferreira Dos Santos A, Porto Freitas F, Chen Z, Sun S, Donate Castillo M, Nepachalovich P, Seufert L, Bothe S, Tschuck J, Mathur A, Nunes-Alves A, Buhr J, Aponte-Santamaría C, Schmitz W, Mack M, Eilers M, Bargou R, Chaufan M, Kaur M, Palma M, Ubellacker JM, Elling U, Augustin HG, Hadian K, Meierjohann S, Proneth B, Conrad M, Fedorova M, Alborzinia H, Friedmann Angeli JP.
Nat Cell Biol. 2026 Mar 13. doi: 10.1038/s41556-025-01856-x. Online ahead of print.PMID: 41826699
- Outcomes and future activities of the ‘Pan-European network in Lipidomics and EpiLipidomics - EpiLipidNET’.
Kuligowski J, Bertrand-Michel J, Cazenave-Gassiot A, Goracci L, Domingues P, Orešič M, Thorsteinsdottir M, Gruber F, Willighagen EL, Spickett CM, Ruskovska T, O’Donnell VB, Prabutzki P, Petrović S, Godzien J, Tortorella S, Reis A, Dias IHK, Schleyer G, Domingues R, Fedorova M.
Metabolomics. 2026 Mar 11;22(2):42. doi: 10.1007/s11306-026-02396-7.PMID: 41813872 Free PMC article. Review.
- Prostaglandins in cancer revisited: principles of production, mechanisms of immune regulation, and therapeutic perspectives.
Müller E, Kruse B, Böttcher JP.
Blood. 2026 Feb 12;147(7):713-724. doi: 10.1182/blood.2025029806. PMID: 41288533 Review.
- Tolerance to ferroptosis facilitates lipid metabolism and pathogenic type 2 immunity in allergic airway inflammation.
Wientjens C, Doverman M, Zurkovic J, More T, Surendar J, Nesic S, Sarici C, Utecht TD, Pohl J, Pollock J, Voehringer D, Hiller K, Thiele C, Wilhelm C.
Immunity. 2026 Feb 10;59(2):322-338.e9. doi: 10.1016/j.immuni.2025.11.018. Epub 2025 Dec 10. PMID: 41380684
- Wnt-associated DKK3 in keratinocytes mediates radiation-induced hyperplasia, dermatitis and skin fibrosis.
Li L, Lopez Perez R, Shehzad K, Jennemann R, Schmidt C, Walle T, Tietz-Dahlfuß A, Grimm E, Kraske JA, Häring P, Barayeu U, Dick TP, Ye L, Braun SA, Hertl M, Worzfeld T, Wiech T, Ji H, Su J, Schneeweiss JM, Liu M, Kommoss K, Heikenwälder M, Zou B, Mücklich S, Steinbrink K, Raker VK, Wu W, Noessner E, Gröne HJ, Nelson PJ, Sandhoff R, Huber PE.
Signal Transduct Target Ther. 2026 Feb 2;11(1):41. doi: 10.1038/s41392-025-02541-z.PMID: 41629266
- Iron-related intercellular communication in the liver: Main players and mechanisms.
Fonseca Ó, Oliveira PJ, Muckenthaler MU, Moreira AC, Gomes MS.
Eur J Clin Invest. 2026 Jan;56(1):e70168. doi: 10.1111/eci.70168. Epub 2026 Jan 7.PMID: 41502243
- A fin-loop-like structure in GPX4 underlies neuroprotection from ferroptosis.
Cell. 2026 Jan 8;189(1):287-306.e35. doi: 10.1016/j.cell.2025.11.014. Epub 2025 Dec 4. PMID: 41349546 - Targeting FSP1 triggers ferroptosis in lung cancer.
Wu K, Vaughan AJ, Bossowski JP, Hao Y, Ziogou A, Kim SM, Kim TH, Nakamura MN, Pillai R, Mancini M, Rajalingam S, Han M, Nakamura T, Wang L, Chung S, Simeone D, Shackelford D, Kang YP, Conrad M, Papagiannakopoulos T.
Nature. 2026 Jan;649(8096):487-495. doi: 10.1038/s41586-025-09710-8. Epub 2025 Nov 5. PMID: 41193800 Free PMC article.
- Lymph node environment drives FSP1 targetability in metastasizing melanoma.
Palma M, Chaufan M, Breuer CB, Müller S, Sabatier M, Fraser CS, Szylo KJ, Yavari M, Carmona A, Kaur M, Melo LMN, Cansiz F, Monge-Lorenzo J, Flores M, Mishima E, Nakamura T, Proneth B, Labrado M, Liang Y, Cayting N, Zheng L, Cañeque T, Colombeau L, Wahida A, Friedmann Angeli JP, Tasdogan A, Hui S, Rodriguez R, Conrad M, Reticker-Flynn NE, Ubellacker JM.
Nature. 2026 Jan;649(8096):477-486. doi: 10.1038/s41586-025-09709-1. Epub 2025 Nov 5. PMID: 41193799 Free PMC article.
